Screening pre-diabetes and obese women in an early stage of renal dysfucntion from serum 25- hydroxy vitamin D and serum parathormone levels with age, body mass index and fast plasma glucose

It is known that vitamin D may affect renal homeostasis and is inversely correlated with serum parathormone (PTH). We proposed some classes of levels of serum 25hydroxyvitamin D (25(OH)D) and PTH, we wondered whether fast plasma glucose concentrations or less costly criterion as Age or BMI could be used to predict classification of each woman of our cohort in classes of serum 25(OH)D/PTH concentrations. Measurements of serum 25(OH)D and serum PTH were done, among 165 adult African migrants women. ROC analysis was used to identify serum 25(OH)D and serum PTH thresholds. Machine-learning tools were performed to predict classes of 25(OH)D and serum PTH levels from age, body mass index and fast plasma glucose. A threshold of serum 25(OH)D of 50 ± 5 nmol/L and serum PTH of 44 ± 6 ng/L level was found with a sensitivity of 86%, a specificity of 83%. We identified 40% of the sample as forties women, obese and pre-diabetic in an early stage of kidney disorders. Estimation with Fast Capillary Glucose measurement instead of Fast Plasma Glucose could be a less costly method to screen glucose and vitamin D status among migrant women.